South Carolina has no specific law or regulation requiring employers to conduct fire drills, with the exception of schools, colleges, adult and child daycare facilities, and residential medical facilities and nursing homes.
However, South Carolina's Occupational Safety and Health Act (OSH Act) requires that companies with 10 or more employees have written fire prevention and emergency exit plans in place for each worksite. Employers with fewer than 10 employees may communicate the plans orally. South Carolina's OSH Act virtually mirrors the federal OSH Act, with a few exceptions.
There is a more detailed discussion of the federal OSH Act emergency and fire plan requirements. Also check local fire safety codes, which may contain additional requirements.